Researchgradient boostingprotein variantssequence deletionsvariants of uncertain significance
PON-Del Predicts Sequence-Retaining Protein Deletions Accurately
8.3
Relevance ScoreZhang, Kabir and Vihinen publish PON-Del (Feb 25, 2026), a gradient boosting–based predictor for 1–10 amino acid sequence-retaining protein deletions. Trained on an extensive verified dataset, PON-Del is the first deletion tool to include three-state outputs (pathogenic, benign, variants of uncertain significance) and outperforms prior methods; code and data are publicly available.
