Yale Researchers Develop Immunostruct For Vaccine Design

Yale researchers publish Immunostruct in Nature Machine Intelligence, a multimodal machine-learning model (amino-acid sequences, 3D structure, biochemical properties) that predicts immunogenic peptide epitopes. They trained and validated the model on cancer and immunology datasets, reporting improved candidate identification versus sequence-only models. The open-source model and a spinout license aim to accelerate personalized epitope vaccine design for cancer and emerging infectious variants.