Researchers Reveal Andes Virus Gn-Gc Structure

Researchers at The University of Texas at Austin report in Cell that they solved the Andes hantavirus Gn-Gc tetramer structure at 2.3-angstrom resolution and created a vaccine candidate that elicited neutralizing antibodies in mice. Using cryo-electron microscopy on virus-like particles and selective particle orientation, the study corrects prior 12-Å models and provides an atomic blueprint to guide stabilizing mutations and antibody design.