GPT-4 Improves Clinical Guideline Readability With Caveats

In a 2026 study, researchers applied a GPT-4–based pipeline to 20 NHS Injectable Medicines Guide (IMG) guidelines to improve readability while preserving content. BERT scores showed high semantic similarity (0.88–0.96), and SMOG readability improved modestly (mean difference 0.32; P=.02), but pharmacists identified omissions or changes in 20% of subsections, so authors caution against unverified automated edits.