Researchers Map Tau Modifications Across Tauopathies

Boston Children's Hospital researchers led by Judith A. Steen and Hanno Steen analyzed brain tissue from 203 patients across multiple tauopathies using FLEXITau mass spectrometry to absolutely quantify 145 post‑translational modifications and 195 cleavage sites. Machine‑learning models ranked disease‑discriminant molecular features, producing a validated molecular atlas that aims to guide precision diagnostics, imaging, and therapeutic target selection across tau-mediated neurodegeneration.