Histo-Miner Extracts Tissue Features From cSCC

Sancéré et al. (published Jan 21, 2026) present Histo-Miner, a deep-learning pipeline for H&E whole-slide images of cutaneous squamous cell carcinoma, trained on datasets with 47,392 annotated nuclei across five cell types in 21 WSIs and tumor-region segmentation in 144 WSIs. Models achieve nucleus mPQ 0.569, macro F1 0.832 and tumor mIoU 0.907, and the pipeline predicts immunotherapy response on 45 patients with mean AUC 0.755±0.091.